A plain-language directory for people who are tired, stuck, or looking for a next step, including care for depression that has not responded to standard treatment. Start with the basics, then find providers by region.
Most people do not start by looking for a specific medication. They start with something like "help with depression" or "antidepressants are not working." This directory is organized to meet you there.
Short, honest explainers on talk therapy, medication, and the newer options used when standard care has not helped.
Real, well-known Missouri and regional programs, each with one honest line about who they serve.
Call a program, ask your own doctor, or reach a crisis line. Any of these counts as progress.
These are real, established organizations. Services, insurance, and wait times change often, so confirm details directly with each provider. Listings are ordered with our featured local partner first, then the rest alphabetically.
A physician-led mental-health clinic focused on treatment-resistant depression and PTSD. They offer FDA-approved esketamine (Spravato) and TMS (transcranial magnetic stimulation) for people who have not found relief from standard antidepressants and therapy. Most insurance is accepted, including MO HealthNet.
A large academic psychiatry program tied to Washington University School of Medicine, offering evaluation and treatment for mood disorders, including complex and difficult-to-treat cases.
A community behavioral-health provider serving the St. Louis area with outpatient care, medication management, and support for people who may be uninsured or on Medicaid.
One of the larger behavioral-health nonprofits in central and southwest Missouri, offering therapy, psychiatry, and crisis services across many communities.
A statewide network of community health and behavioral-health clinics. A practical starting point for affordable outpatient mental-health care and medication management.
An outpatient behavioral-medicine group offering therapy and specialty programs for anxiety, depression, OCD, and related conditions in the St. Louis area.
Part of MU Health Care, this program provides inpatient and outpatient psychiatric care, including for severe mood and trauma-related conditions.
Listing note: aside from the clearly labeled sponsored partner, providers above are included because they are real, established Missouri or regional organizations. Inclusion is not an endorsement, and this is not a complete list of care in the state.
If you are near St. Louis or St. Charles County and you have already tried therapy and one or more antidepressants without lasting relief, it is worth asking about advanced options. Brain Recovery Centers is a doctor-supervised clinic offering FDA-approved esketamine (Spravato) and TMS for treatment-resistant depression and PTSD, and they accept most insurance including MO HealthNet.
Learn more at Brain Recovery Centers →Disclosure: Brain Recovery Centers is a recommended partner of this directory. We suggest them because they serve this region and offer treatments that are hard to find locally.